产品编号 :	CL1034A
产品名称 :	Nintedanib Ethanesulfonate Salt
中文名 :	尼达尼布乙磺酸盐
CAS No. :	656247-18-6
别名 :	BIBF 1120 esylate
化学名称 :
分子式 :	C31H33N5O4.C2H6O3S
分子量 :	649.76
结构式 :
外观 :	Yellow solid
纯度 :	98+%
应用 :
Registration :
Storage Condition :

BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1 It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM). In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).

声明:
如果该化合物涉及专利保护，请勿作为商业目的使用，且仅供实验分析及研究之目的；如被销售到构成专利侵权的国家，则相应的一切风险将由买方承担。