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2017新年热销产品推荐:雷公藤红素 Celastrol(Tripterine) CAS: 34157-83-0

日期2017-2-4  点击:525
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雷公藤红素 Celastrol(Tripterine) CAS: 34157-83-0
CAS: 34157-83-0
ChemicalName:(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
M.Wt:450.61
Formula:C29H38O4
Solubility:Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:>99%
Storage:Store at -20°C
Biological Activity:
Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).
References:
Sethi et al (2007) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 109 2727. PMID: 17110449.
Nagase et al (2003) Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 67 1883. PMID: 14519971.
Sassa et al (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 172 890.
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