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A 83-01

  Catalogue No. : C16287
  Product Name: A 83-01
  Synonym: A83-01;A-83-01;ALK5 Inhibitor IV;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV
  Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
  CAS No. : 909910-43-6
  Structure :
  Molecular Formula: C25H19N5S
  Molecular Weight: 421.52
  Purity: >98%
  Usage: Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.
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