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Panobinostat(LBH-589)
| 产品编号 : |
C13981 |
| 产品名称： |
Panobinostat(LBH-589) |
| 英文名： |
Panobinostat(LBH-589) |
| 别名： |
LBH589;Panobinostat;LBH-589;NVP-LBH-589 |
| 化学名称： |
N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide |
| CAS No. ： |
404950-80-7 |
| 结构式 ： |
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| 分子式： |
C21H23N3O2 |
| 分子量： |
349.43 |
| 纯度： |
>98% |
| Usage: |
Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. |
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| 如果该化合物涉及专利保护，请勿作为商业目的使用，且仅供实验分析及研究之目的；如被销售到构成专利侵权的国家，则相应的一切风险将由买方承担。 |
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