Product Number :	CL1011
Product Name :	ICG-001
CAS No. :	780757-88-2
Synonyms :	ICG 001; ICG001
Chemical Name :	(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Molecular Formula :	C33H32N4O4
Molecular Weight :	548.63
Molecular Structure :
Appearance :	White or white crystalline powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Biological Activity: Specific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.

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