Product Number :	CL1009
Product Name :	4-Hydroxytamoxifen
CAS No. :	68047-06-3
Synonyms :	trans-4-Hydroxytamoxifen
Chemical Name :	(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
Molecular Formula :	C26H29NO2
Molecular Weight :	387.52
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :
Registration :
Storage Condition :

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen. It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner. 

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