Product Number :	CL1968
Product Name :	Ciclesonide
CAS No. :	126544-47-6
Synonyms :	RPR251526
Chemical Name :
Molecular Formula :	C32H44O7
Molecular Weight :	540.69
Molecular Structure :
Appearance :	White-like crystalline powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC). CIC binds to the glucocorticoid receptor with a Ki value of 37 nM. It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.

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