Product Number :	CL2205
Product Name :	Darunavir
CAS No. :	206361-99-1
Synonyms :	TMC114
Chemical Name :
Molecular Formula :	C₂₇H₃₇N₃O₇S
Molecular Weight :	547.66
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Darunavir is a drug used to treat HIV infection. It is in the protease inhibitor class. Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC50 of 0.003 μmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents. 

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