Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel.It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM).In vivo, docetaxel inhibits tumor growth in several cancer models, including B16 murine melanoma and P388 murine leukemia models. Formulations containing docetaxel have been used in the treatment of head and neck, breast, and non-small cell lung cancer, gastric adenocarcinoma, and castration-resistant prostate cance
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