Product Number :	CL2346
Product Name :	Navitoclax
CAS No. :	923564-51-6
Synonyms :	ABT-263
Chemical Name :
Molecular Formula :	C47H55ClF3N5O6S3
Molecular Weight :	974.61
Molecular Structure :
Appearance :	White to light yellow powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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