| Product Number : |
CL2485 |
| Product Name : |
PD184352(CI-1040) |
| CAS No. : |
212631-79-3 |
| Synonyms : |
CI-1040 |
| Chemical Name : |
|
| Molecular Formula : |
C17H14ClF2IN2O2 |
| Molecular Weight : |
478.66 |
| Molecular Structure : |
 |
| Appearance : |
White to off-white powder |
| Specification : |
98+% |
| Application : |
|
| Registration : |
|
| Storage Condition : |
PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity. In cell-based assays, it inhibits MEK1/2 with IC50 values of 17 nM and exhibits a 100-fold preference for MEK1/2 over MEK5. In mouse xenograft models, it exhibits strong in vitro anti-proliferative activity and significant in vivo antitumor efficacy.
Statement:
->>Products covered by valid patents are not offered or supplied for commercial use.
->>Products currently covered by valid US Patents are offered for laboratory R&D use in accordance with 35 USC 271(e)+A13(1).
->>Any patent infringement and resulting liability is solely at buyer's risk.
->>Our products are only raw materials for drugs or industry, can't be used for human or animals directly.
