Product Number :	CL2330
Product Name :	CO-1686(Rociletinib)
CAS No. :	1374640-70-6
Synonyms :	CO-1686
Chemical Name :
Molecular Formula :	C27H28F3N7O3
Molecular Weight :	555.55
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Rociletinib, also known as AVL-301 and CO1686, is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor CO-1686 binds to and inhibits mutant forms of EGFR, including T790M, thereby leading to cell death of resistant tumor cells. Compared to other EGFR inhibitors, CO-1686 inhibits T790M, a secondary acquired resistance mutation, as well as other mutant EGFRs and may have therapeutic benefits in tumors with T790M-mediated resistance to other EGFR tyrosine kinase inhibitors.

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