Romiplostim(AMG531,Romiplate) is a thrombopoietin receptor agonist (TPO-RA), a TPO analogue, and a Fc-peptide fusion protein (peptide body).
The peptide body molecule consists of two identical single-stranded subunits, each consisting of the Fc domain of human immunoglobulin IgG1, covalently linked at the cterminal to a peptide containing two thrombopoietin receptor binding domains.
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