Product Number :	CL1016
Product Name :	Streptozotocin
CAS No. :	18883-66-4
Synonyms :	Streptozocin
Chemical Name :
Molecular Formula :	C8H15N3O7
Molecular Weight :	265.22
Molecular Structure :
Appearance :	Light yellow powder
Specification :	98+%
Application :
Registration :
Storage Condition :

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

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