| Product Number : |
CL1896 |
| Product Name : |
Vandetanib |
| CAS No. : |
443913-73-3 |
| Synonyms : |
ZD6474 |
| Chemical Name : |
|
| Molecular Formula : |
C22H24BrFN4O2 |
| Molecular Weight : |
475.35 |
| Molecular Structure : |
 |
| Appearance : |
White Powder |
| Specification : |
98+% |
| Application : |
|
| Registration : |
|
| Storage Condition : |
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).
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->>Products covered by valid patents are not offered or supplied for commercial use.
->>Products currently covered by valid US Patents are offered for laboratory R&D use in accordance with 35 USC 271(e)+A13(1).
->>Any patent infringement and resulting liability is solely at buyer's risk.
->>Our products are only raw materials for drugs or industry, can't be used for human or animals directly.
